ABSTRACT
Objective:To explore the predictive value of brachial-ankle pulse wave velocity (baPWV)>1 400 cm/s in fragility fracture in middle-aged and elderly population.Methods:From May to October 2011, questionnaire survey was conducted on a total of 3 265 males over 50 years old and postmenopausal females in Yunyan District, Guiyang City, and physical examination was carried out to measure their metabolic related indicators such as blood lipids, QUS calcaneus bone densities, and brachial-ankle pulse wave velocities. According to their baPWV, the enrolled subjects were divided into a normal baPWV group and an elevated baPWV group. Follow-up was performed for 38 months, and the incidence of fractures was tracked. Finally, 2 637 subjects with complete baseline and follow-up data were enrolled in this research for analysis.Results:The 3-year total incidence of fragility fracture was 5.08%. In particular, the rate of fragility fractures among males in the normal baPWV group was 1.6%, and that in the elevated baPWV group was 2.0%. There was no statistically significant difference between the two groups ( P>0.05). The rate of fragility fracture events among postmenopausal females in the normal baPWV group was 4.4%, and that in the elevated baPWV group was 7.1%. There was statistically significant difference between the two groups ( P<0.05). Further multivariate COX regression (or proportional hazards regression) analysis showed that the bone density T value ( HR 0.839, 95% CI 0.741-0.952, P=0.006) and baPWV ( HR 1.700, 95% CI 1.046-2.763, P=0.042) were related with risk of fragility fractures in postmenopausal women. Conclusion:A baPWV greater than 1 400 cm/s could be independently associated with the risk of fragility fractures in postmenopausal females and might be an independent risk factor for predicting fragility fractures. However, such differences were not as evident in middle-aged and elderly male patients.
ABSTRACT
Objective To investigate the accumulative 3-year morbidity of diabetes in the residents aged 40 years and above in a community of Guiyang and the risk factors. Methods A total of 10140 permanent residents aged over 40 years in a community of Guiyang were selected from May 2011 to October 2011 using randomized sampling. This population was followed up again in 2014. Questionnaires, physical examination, blood lipids and oral glucose tolerance test were performed among the subjects of study for two surveys with the same criteria. Finally, 5958 subjects with complete data and without baseline diabetes at the two time points were enrolled in this study for analysis. Results The 3-year accumulative morbidity of diabetes in this population was 6. 13％ (6. 59％ in males, 5. 65％ in females). The main factors influencing the incidence of diabetes mellitus were age (OR = 1. 589, 95％ CI 1. 395-1. 809, P<0. 01), body mass index ( OR = 2. 012, 95％ CI 1. 632-2. 479, P<0. 01), pulse rate ( OR =1. 019, 95％ CI 1. 012-1. 025, P<0. 01), family history (OR = 1. 700, 95％ CI 1. 299-2. 225, P<0. 05), fasting plasma glucose at baseline(OR = 3. 132, 95％ CI 2. 478-3. 958, P<0. 01), 2 h plasma glucose at baseline( OR =1. 698,95％ CI 1. 574-1. 832, P < 0. 01), total cholesterol ( OR = 1. 350, 95％ CI 1. 060-1. 719, P < 0. 05), triglyceride(OR=2. 196, 95％ CI 1. 758-2. 743, P<0. 01),high density lipoprotein-cholesterol(OR = 0. 540, 95％CI 0. 375-0. 776, P < 0. 01), and low density lipoprotein-cholesterol ( OR = 1. 614, 95％ CI 1. 094-2. 382, P<0. 05). Conclusion 3-year morbidity of diabetes in Guiyang was 6. 13％ . The incidence of diabetes is notably correlated with aging, faster pulse frequency, overweight and obesity, higher baseline blood glucose, and dyslipidemia.